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CSU Animal Cancer Center Clinical Trial

Patient Disease:
Canine Osteosarcoma

Study Name:
Reversal of Tumor Immune Suppression with Losartan and Toceranib for Treatment of Osteosarcoma Metastases

Purpose of the study:

  • Toceranib and losartan have been shown to inhibit certain immune cells to allow the immune system to better recognize cancer
  • This study assesses this combination of medications used specifically in patients with osteosarcoma.

Primary Eligibility Criteria:

  • Dogs with confirmed osteosarcoma
  • Have undergone surgical resection of the primary tumor, and have lung metastases visible on chest x-rays.
  • Systemically healthy otherwise.

Study Protocol:

  • Initial diagnostic testing to ensure eligibility for study
  • Oral losartan given at home twice daily alone for first 2 weeks, then oral toceranib added which is administered at home every other day.
  • Rechecks at 1, 2, 4, and 8 weeks, and then every 4 weeks after that; dog must stay at hospital for full day at 2 week visit for blood sample collections for study purposes.

Owner Responsibilities:

  • Follow appointment schedule required by study protocol
  • Be comfortable administering oral medications

Financial Incentives:

  • Toceranib and losartan will be provided at no cost
  • Chest x-rays done every 8 weeks will be paid for by study

If you have further questions about any of our clinical trials, Please either login or sign up to submit a consulting form. Your consult will then be directed to an appropriate oncology clinician. Requests are typically returned within 5 business days