FACC home

clinical team

clinical trials

treatment options

about cancer

ways to give

saying goodbye

CSU pet hospice

emotional support

related links

join our mailing list
join our mailing list
events calendar

There are no events to display for this time period.

Follow us on Facebook Veterinary Teaching Hospital
CSU Campaign
Advancing Cancer Treatment
| Share

CSU Animal Cancer Center Clinical Trial

Patient Disease:
Canine Osteosarcoma

Study Name:
Reversal of Tumor Immune Suppression with Losartan and Toceranib for Treatment of Osteosarcoma Metastases

Purpose of the study:

  • Toceranib and losartan have been shown to inhibit certain immune cells to allow the immune system to better recognize cancer
  • This study assesses this combination of medications used specifically in patients with osteosarcoma.

Primary Eligibility Criteria:

  • Dogs with confirmed osteosarcoma
  • Have undergone surgical resection of the primary tumor, and have lung metastases visible on chest x-rays.
  • Systemically healthy otherwise.

Study Protocol:

  • Initial diagnostic testing to ensure eligibility for study
  • Oral losartan given at home twice daily alone for first 2 weeks, then oral toceranib added which is administered at home every other day.
  • Rechecks at 1, 2, 4, and 8 weeks, and then every 4 weeks after that; dog must stay at hospital for full day at 2 week visit for blood sample collections for study purposes.

Owner Responsibilities:

  • Follow appointment schedule required by study protocol
  • Be comfortable administering oral medications

Financial Incentives:

  • Toceranib and losartan will be provided at no cost
  • Chest x-rays done every 8 weeks will be paid for by study

If you have further questions about any of our clinical trials, Please either login or sign up to submit a consulting form. Your consult will then be directed to an appropriate oncology clinician. Requests are typically returned within 5 business days