Colorado State University Animal Cancer Center
Advancing Cancer Research
 
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Steven Dow

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Name of Investigator: Steven Dow
Title: Professor
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Contact Information:
Email Address: steven.dow@colostate.edu
Work Address (mailing): CSU Animal Cancer Center, Veterinary Teaching Hospital, 1678 Campus Delivery, 300 W. Drake Rd., Fort Collins, CO 80523
Office Location (Building/Room #): ACC 250
Office Phone Number: (970) 497-4014
Laboratory Location (Building/Room #): ACC 255
Laboratory Phone Number: (970) 497-4088		   Steven Dow
       

Biography of Investigator:
DVM: University of Georgia
Residency Internal Medicine: Colorado State University
Ph.D. (Comparative Pathology): Colorado State University
Post-Doc and Instructorship: National Jewish Medical and Research Center
Associate and Full Professor: Colorado State University

Classes Taught/Currently Teaching:

  • Cancer Biology
  • Immunity to Infection
  • Immunobiology
  • Post-graduate Medicine

Research Focus:
Our lab focuses on understanding how the immune system responds to tumors and how stimulation of the immune system through vaccines or immunotherapy can be utilized to improve tumor responses.  Currently we are investigating the role that monocytes and macrophages play in suppressing antitumor immunity and in using various strategies to deplete these cells as a new approach to cancer therapy.  We are also investigating how chronic bone infection may stimulate the immune system to suppress tumor metastasis.  The insight we gain from these studies could be used to design new immunotherapies for dogs and humans with bone cancer.  We are also studying how sustained administration of low-doses of chemotherapy can be used to augment antitumor immunity and suppress tumor angiogenesis.

Name of Laboratory:
Tumor Immunology


Laboratory Personnel:
Amanda Guth, Ph.D., DVM: Post-doctoral fellow
Joe Sottnik, MS: Graduate student
Scott Hafeman, DVM: Graduate student
Ryan Richmond: Undergraduate Researher
Maura Lydon: Undergraduate Researher
Erin McQuinn: Undergraduate Researher
Genevieve Foster: Undergraduate Researher


List of Major Laboratory Equipment:

  1. Flow cytometry
  2. ELISA reader


Current Work/Projects:

  1. Role of Monocytes in Tumor Development
  2. Macrophage Depletion Therapy for Cancer
  3. Effects of Metronomic Therapy on Tumor Angiogenesis and T Cell Responses
  4. Liposomal Delivery of Bisphosphonates for Macrophage Depletion in Cancer

Oncology Resident:
Jim Perry, Ph.D., DVM: Post-doctoral fellow

 

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