Anne Avery

Name of Investigator: Anne Avery
Title: Associate Professor
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Contact Information:
Email Address: anne.avery@colostate.edu
Work Address (mailing): 200 West Lake Street, Fort Collins, CO 80523
Office Location (Building/Room #): Pathology 231
Office Phone Number: (970) 491-6138
Laboratory Location (Building/Room #): Pathology 202, 203, 205
Laboratory Phone Number: (970) 491-1170

Biography of Investigator:
Undergrad: Mount Holyoke College
Ph.D.: Cornell University
VMD: University of Pennsylvania
Internship: University of Pennsylvania
Post Doc: Dana-Farber Cancer Institute, Harvard Medical School

Classes Taught/Currently Teaching:
Lectures in: Veterinary Immunology, Bioanalytical Pathology, Immunobiology, Immunity to Infection, Laboratory Animal Pathology, Immunology Laboratory, Principles and Mechanism of disease

Research Focus:
The main interest of our laboratory is the study of infectious and neoplastic diseases involving the immune system. The basic science portion of our laboratory focuses on malaria research using mouse models of this disease.

The clinical portion of our laboratory is dedicated to providing diagnostic services for cases of suspected lymphoma and leukemia in canine and feline patients. We also use the service to support the development of new diagnostic tests, such as the identification of prognostic markers in canine T cell leukemia using gene expression profiling. Our extensive dataset of phenotypically characterized lymphomas and leukemias has been useful for identifying prognostic factors, and provides epidemiological data on different subtypes of lymphoma and leukemia. Such data has been used to identify breed predisposition to different subcategories of hematologic neoplasia, which can eventually lead to the discovery of genes involved in the development of lymphoid neoplasia.

Name of Laboratory:
Clinical Immunology Laboratory

List of Major Laboratory Equipment

1. Flow cytometer
2. iCycler
3. Dako Automated Stainer

Current Work/Projects:

1. Development of a real time PCR assay for detection of bcr-abl
2. Gene expression profiling in T cell leukemia for detection of prognostic markers
3. Prognosis in feline leukemia
4. Cytokine and acute phase proteins in Shar-pei fever, an autoinflammatory disorder

Publications:
Burnett, RC, Vernau, W, Modiano, JF, Olver, CS, Moore, PF, Avery, AC. 2003. Diagnosis of canine lymphocytic neoplasia using clonal rearrangements of antigen receptor genes. Veterinary Pathology. 40:32-41.

Burnett, RC, Blake, MK, Thompson, LJ, Avery, PR Avery, AC. 2004. The evolution of a B cell lymphoma to multiple myeloma following chemotherapy. Journal of Veterinary Internal Medicine. 18:768 - 771.

Keller, RL, Avery, AC, Burnett, RC, Walton, JA and Olver, CS. 2004. Detection of canine lymphoma in peripheral blood using polymerase chain reaction for antigen receptor gene rearrangement (PARR). Veterinary Clinical Pathology.33:145 - 149.

Wilkerson, MJ, Dolce, K, Koopman, T, Shuman W, Chun. R, Garrett, L, Barber, L, Avery, AC. 2005. Lineage differentiation of canine lymphoma/leukemias and aberrant expression of CD molecules. Veterinary Immunology and Immunopathology. 106:179-196.

Modiano, JF, Breen, M, Burnett, RC, Parker, HG, Inusah, S, Avery, PR, Ostrander, EA, Cutter, GC, Avery, AC. 2005. Distinct prevalence of B and T cell lymphoproliferative diseases among dog breeds is an indicator of heritable risk. Cancer Research, 65:5654-5661.

Lana, SE, Jackson, TL, Burnett, RC, Morley, P, Avery, AC. 2006. The utility of PCR for analysis of antigen receptor rearrangement in staging and predicting prognosis in dogs with lymphoma. Journal of Veterinary Internal Medicine. 20:329-334.

Lana, S, Plaza, S, Hampe, K, Burnett, R and Avery, AC. 2006. Diagnosis of mediastinal masses by flow cytometry. Journal of Veterinary Internal Medicine. 20:1161-1165.

Kisseberth WC, Nadella MVP, Breen M, Thomas R, Duke SE, Murahari S, Kosarek CE, Vernau W, Avery AC, Burkhard MJ, Rosol TJ. 2007. A novel canine lymphoma cell line: a translational and comparative model for lymphoma research. Leukemia Res. 31:1709 - 1720.

Williams, MJ, Avery, AC, Lana, SE, Hillers, KH, Bachand, A, Avery, PR. 2008. Canine lymphoproliferative disease characterized by lymphocytosis: immunophenotypic markers of prognosis. Journal of Veterinary Internal Medicine. 22:596-601.

Biller, BJ, Elsmlie, RE, Burnett, RC, Avery, AC, Dow, SW. 2007. Use of foxp3 expression to identify regulatory T cells in healthy dogs and dogs with cancer. Veterinary Immunology and Immunopathology. 116:69-78.

Allison, RW, Brunker, JD, Breshears, MA, Avery, AC, Moore, PF, Affolter, VK, Vernau, W 2008. Dendritic cell leukemia in a Golden Retriever. Veterinary Clinical Pathology. 37:190-197.

Miller, AG, Avery, AC, Lana, SE, Olver, CS 2008. Cancer related anemia in dogs-anemia is associated with decreased survival time in dogs with lymphoma. (In press.)

Avery, PR and Avery, AC. 2004. Molecular methods to distinguish reactive and neoplastic lymphocyte expansion, Invited Review. Veterinary Clinical Pathology. 33:196 - 207

Modiano, JF, Breen, M, Avery, AC, London, CA. 2005. Breed-Specific Canine Lymphoproliferative Disorders, In: The Dog and its Genome (editors Ostrander, E., Giger, U., Lindblad-Toh, K.). Cold Spring Harbor Press. 2005.

Avery, PR, Avery, AC. Determining the significance of persistent lymphocytosis. 2007. Veterinary Clinics of North America, 37:267-282.

Lana, SE, Avery, AC, 2007. Canine Lymphoma, In: Kirk's Current Veterinary Therapy XIV (editor John Bonagura), Saunders. (In press.)

Ramos-Vera, J., Avery, A.C., Avery, P.R. Advanced Diagnostic Techniques, In: Canine and Feline Cytology: A Color Atlas and Interpretation Guide, Elseiver, Eds. Raskin, R. and Meyer, D. (In press.)

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