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CSU Animal Cancer Center Clinical Trial

Patient Disease:
Canine Osteosarcoma

Study Name:
Predictive Models of Drug Response in Canine Osteosarcoma: A Prospective Clinical Trial Testing the COXEN Approach

Purpose of the study:

  • Use a model (COXEN) to predict which of the standard chemotherapy protocols an individual dog’s tumor is most sensitive to
  • Administer (post amputation) chemotherapy to the patient based on the predictions generated by the model
  • Determine if this gives better outcomes for those patients (longer survival)

Primary Eligibility Criteria:

  • Dogs with confirmed or suspected diagnosis of osteosarcoma of a limb, with no evidence of metastases (chest x-rays)
  • Dogs must be free of other serious diseases (physical exam, blood tests)
  • All dogs must have amputation as the treatment of the tumor, performed at CSU
  • They cannot have had any prior treatment for the tumor

Study Protocol:

  • Initial screening tests (physical exam, blood and urine test, x-rays of the affected limb and chest)
  • Surgery to amputate limb (tumor samples will be analyzed by COXEN method)
  • Further visits will be for blood tests, chemotherapy treatments (determined based on COXEN results of tumor analysis),  and intermittent chest x-rays

Owner Responsibilities:

  • To make and keep all study related appointments
  • Owner is responsible for finances, aside from the points listed below

Financial Incentives:

  • The study pays for the cost of the COXEN analysis to determine drug sensitivity of tumor
  • The study pays for chest x-rays until the development of metastatic disease
  • The owner would be responsible for all other costs associated with the dogs treatment and participation in this study

If you have further questions about any of our clinical trials, Please either login or sign up to submit a consulting form. Your consult will then be directed to an appropriate oncology clinician. Requests are typically returned within 5 business days