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CSU Animal Cancer Center Clinical Trial

Patient Disease:
Any Canine Neoplasia Accessible for Biopsy

Study Name:
Pilot, Open-Label, phase-1 Study of svL4 in Tumor-Bearing Dogs

Purpose of the study:

  • To evaluate the safety and immune effects of svL4 when given to dogs with cancer once every other day
    • svL4 is a small protein that has been shown to stimulate certain cells of the immune system in mice, and in canine immune cells in the laboratory; this may result in production of compounds by the immune system that can help to control cancer

Primary Eligibility Criteria:

  • Dogs with a confirmed diagnosis of cancer that is accessible for biopsy
  • 2 week washout from chemotherapy, 6 weeks from radiation therapy, 72 hours from corticosteroids

Study Protocol:

  • Injections of svL4 given under the skin every other day 
    • Randomized to 2 different doses of svL4
  • Recheck visits required 1 day and 1 & 2 weeks after the first treatment then every other week
  • Blood samples collected at every visit
  • Tumor biopsies performed prior to starting treatment and then 2 weeks after the first treatment
  • Dogs will be eligible to continue svL4 treatment as long as their tumor has not grown significantly and they have not developed any problematic side effects

Owner Responsibilities:

  • Follow appointment schedule required by study protocol
  • Be comfortable administering injections under the skin (you will be trained to do this at home)

Financial Incentives:

  • Study pays for all costs associated with trial except for exam fee at each visit ($43)
  • $750 credit to VTH account which can be used for future treatment after completion of the trial
    • Can also be applied retroactively to cover the costs of initial testing to determine eligibility if your dog is successfully entered into the study

If you have further questions about any of our clinical trials, Please either login or sign up to submit a consulting form. Your consult will then be directed to an appropriate oncology clinician. Requests are typically returned within 5 business days