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CSU Animal Cancer Center Clinical Trial

Patient Disease:
Canine Soft Tissue Sarcoma

Study Name:
Oncolytic Poxvirus Therapy for Soft Tissue Sarcoma in Dogs – Pilot Safety Study

Purpose of the study:

  • To determine if recombinant myxoma virus therapy is safe in dogs with soft tissue sarcoma
    • There are several ongoing clinical trials testing the efficacy of oncolytic virotherapy in humans, but trials in canine cancer patients are extremely rare
    • Mouse models of canine cancers have been successfully treated with oncolytic viruses
    • Clinical trials using oncolytic virotherapy in dogs are the next step in the process of advancing treatment options for dogs with cancer

Primary Eligibility Criteria:

  • Dogs with a histologically confirmed diagnosis of soft tissue sarcoma
    • Biopsy tissue must be available for analysis
  • Tumor must be at least 2 cm in diameter and accessible for biopsies
  • Prior surgery acceptable; 2 week washout from chemotherapy, 6 weeks from radiation therapy
  • Dogs living in household with an immunocompromised person or a rabbit will be ineligible

Study Protocol:

  • Dogs will receive an injection of the poxvirus directly into the tumor
  • Recheck visits are required 1, 4, 7, 14, & 28 days following virus injection for collection of blood, urine, feces, and saliva to monitor for adverse effects and virus shedding
  • Tumor biopsies will be performed on days 4 and 14 following virus injection
  • Study is completed at day 28 visit or earlier if there is evidence of tumor progression or significant adverse effects of virus injection
  • The first three dogs enrolled in this study will need to be hospitalized at CSU for 7 days following the virus injection

Owner Responsibilities:

  • Cost of biopsy prior to starting treatment to confirm diagnosis
  • Follow appointment schedule required by study protocol
  • Complete owner diary daily including documentation of tumor size, weight of dog, and any side effects noted

Financial Incentives:

  • Study pays for all costs associated with trial
  • VTH credit given at completion of trial to be used towards additional treatment
    • $1000 for first 3 dogs enrolled, $500 for others

If you have further questions about any of our clinical trials, Please either login or sign up to submit a consulting form. Your consult will then be directed to an appropriate oncology clinician. Requests are typically returned within 5 business days