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CSU Animal Cancer Center Clinical Trial

Patient Disease:
Cachexia (May be associated with any neoplasm, except those located within the GI tract)

Study Name:
Melanocortin 4 Receptor Antagonist in the Treatment of Canine Cachexia

Purpose of the study:

  • To evaluate effectiveness of a novel therapeutic to increase the body weight and quality of life in dogs experiencing cachexia (weight loss).

Primary Eligibility Criteria:

  • Clinical diagnosis of cachexia- at least 5% loss of body weight in the past 3 months, not reversed by increasing intake of food.

Study Protocol:

  • Initial screening to determine eligibility (physical exam, lab work).
  • Abdominal ultrasound, blood pressure check, 24-hour Holter monitor.
  • Medication administration begins once cardiac status is approved by a cardiologist.
  • Medications are given once daily as an injection under the skin (SQ). There are rechecks at CSU weekly.
  • The Holter monitor (for 24 hours); is repeated at day 28.
  • The clinical trial lasts for 28 days. There is the option to continue the medication off trial which can be discussed at the end of the trial.

Owner Responsibilities:

  • To administer medications as prescribed. You must be comfortable giving daily injections.
  • To make and keep all appointments for the study protocol.

Financial Incentives:

  • Study pays for study procedures (exams, diagnostic testing, and study medication once enrolled in the trial).

If you have further questions about any of our clinical trials, Please either login or sign up to submit a consulting form. Your consult will then be directed to an appropriate oncology clinician. Requests are typically returned within 5 business days