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CSU Animal Cancer Center Clinical Trial

Patient Disease:
Malignant Neoplasia Accessible for Biopsy

Study Name:
COTC024: Defining PK and Biological Activity of Systemic Oncolytic Vesicular Stomatitis Virus (VSV) within a Dose/Schedule Optimization Study

Purpose of the study:

  • To define optimal dose and schedule of administration for systemic VSV treatment in dogs with cancer.
  • VSV is a naturally oncolytic virus that has been engineered to possess potent anti-cancer properties with enhanced safety.

Primary Eligibility Criteria:

  • Dogs that weigh at least 20 kg (44lb)
  • Histological/cytological diagnosis of malignancy
  • Not hemangiosarcoma or mast cell tumor
  • Dog must be feeling well, with adequate routine blood work (blood count, chemistry panel, urinalysis)
  • Dogs must be up to date on all routine vaccinations
  • Must have a 2 week washout from chemotherapy, 7 day washout from corticosteroids, and a 6 week washout from radiation therapy

Study Protocol:

  • Pre-study appointment to determine eligibility: Physical exam and history,  bloodwork, chest x-rays, +/- abdominal ultrasound
  • First day of study (Mondays): Pre-treatment physical exam, tumor measurements, blood samples, lymph node aspirates, tumor biopsies
  • Second day of study (Tuesdays): Virus administration, monitoring and blood sampling
  • Dog must remain in the hospital Tuesday-Friday for in-hospital care, monitoring, and further tumor biopsies and treatment (possible second dose of virus).
  • Once dismissed from the hospital there are weekly appointments until day 29 of the study

Owner Responsibilities:

  • Cost of diagnostics to determine eligibility (bloodwork, urinalysis,  chest x-rays, +/- abdominal ultrasound, histological/cytological confirmation of the diagnosis)
  • To make and keep all appointments, according to clinical trial protocol

Financial Incentives:

  • Once enrolled, the study will pay for all costs associated with the study procedures and treatments
  • Study will also cover cost of side effects attributable to the virus treatment or study procedures (up to  $2000/dog/event)
  • A $1000 credit will be applied to the dog's account at the VTH, which can be applied toward further treatments

If you have further questions about any of our clinical trials, Please either login or sign up to submit a consulting form. Your consult will then be directed to an appropriate oncology clinician. Requests are typically returned within 5 business days