CSU Animal Cancer Center Clinical Trial
Malignant Neoplasia Accessible for Biopsy
COTC024: Defining PK and Biological Activity of Systemic Oncolytic Vesicular Stomatitis Virus (VSV) within a Dose/Schedule Optimization Study
Purpose of the study:
- To define optimal dose and schedule of administration for systemic VSV treatment in dogs with cancer.
- VSV is a naturally oncolytic virus that has been engineered to possess potent anti-cancer properties with enhanced safety.
Primary Eligibility Criteria:
- Dogs that weigh at least 20 kg (44lb)
- Histological/cytological diagnosis of malignancy
- Not hemangiosarcoma or mast cell tumor
- Dog must be feeling well, with adequate routine blood work (blood count, chemistry panel, urinalysis)
- Dogs must be up to date on all routine vaccinations
- Must have a 2 week washout from chemotherapy, 7 day washout from corticosteroids, and a 6 week washout from radiation therapy
- Pre-study appointment to determine eligibility: Physical exam and history, bloodwork, chest x-rays, +/- abdominal ultrasound
- First day of study (Mondays): Pre-treatment physical exam, tumor measurements, blood samples, lymph node aspirates, tumor biopsies
- Second day of study (Tuesdays): Virus administration, monitoring and blood sampling
- Dog must remain in the hospital Tuesday-Friday for in-hospital care, monitoring, and further tumor biopsies and treatment (possible second dose of virus).
- Once dismissed from the hospital there are weekly appointments until day 29 of the study
- Cost of diagnostics to determine eligibility (bloodwork, urinalysis, chest x-rays, +/- abdominal ultrasound, histological/cytological confirmation of the diagnosis)
- To make and keep all appointments, according to clinical trial protocol
- Once enrolled, the study will pay for all costs associated with the study procedures and treatments
- Study will also cover cost of side effects attributable to the virus treatment or study procedures (up to $2000/dog/event)
- A $1000 credit will be applied to the dog's account at the VTH, which can be applied toward further treatments