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CSU Animal Cancer Center Clinical Trial

Patient Disease:
Canine Osteosarcoma

Study Name:

COTC021:  Evaluation of Orally Administered mTOR inhibitor Rapamycin in Dogs in the Adjuvant Setting with Osteosarcoma

COTC022: A Contemporaneous Controlled Study of the Standard of Care (SOC) in dogs with Appendicular Osteosarcoma

Purpose of the study:

  • To determine if the  addition of rapamycin to a standard of care chemotherapy protocol will improve the long term outcome for the patients (COTC 21)
  • To have a control population of dogs treated with standard of care chemotherapy at the same time (COTC 22)
  • Dogs will be assigned to one of the two protocols

Primary Eligibility Criteria:

  • Cytologic or histopathologic confirmation of osteosarcoma diagnosis, of a limb
  • No evidence of metastatic disease
  • Healthy otherwise
  • No prior therapy
  • > 25 kg in weight

Study Protocol:

  • Determine eligibility with initial screening: physical exam, blood tests (CBC, biochemistry, urinalysis), confirmation of osteosarcoma diagnosis, chest x-rays to confirm there are no metastases
  • Surgery- amputation of affected limb
  • Approximately 2 weeks after surgery- start chemotherapy given every 3 weeks for 4 doses
  • Week 15 start rapamycin therapy if on that treatment protocol – will continue for 16 weeks

Owner Responsibilities:

  • To make and keep all study related appointments
  • To have limb amputation surgery performed at CSU
  • To administer rapamycin orally at home to your dog (if assigned to that protocol)
  • To keep a journal when administering rapamycin (if assigned to that treatment protocol)

Financial Incentives:

  • $1000.00 VTH credit to go toward the dog’s surgical amputation
  • The study pays for chemotherapy and all associated costs (appointments, bloodwork, medications)

If you have further questions about any of our clinical trials, Please either login or sign up to submit a consulting form. Your consult will then be directed to an appropriate oncology clinician. Requests are typically returned within 5 business days